RESEARCH STATEMENTS

FROM THE NATIONAL CANCER INSTITUTE AND THE NATIONAL CANCER SOCIETY

The following statements were made by the National Cancer Institute (a federally funded health institute) and the American Cancer Society…”

“Chemical components of Cannabis, called cannabinoids, activate specific receptors found throughout the body to produce pharmacologic effects, particularly in the central nervous system and the immune system” (1)

“Endogenous cannabinoids (endocannabinoids) have been identified and appear to have a role in, for example, pain modulation, control of movement, feeding behavior, and memory” (3)

“Cannabinoids may have benefits in the treatment of cancer-related side effects” (1)

“The potential benefits of medicinal Cannabis for people living with cancer include antiemetic effects, appetite stimulation, pain relief, and improved sleep” (2)

“Cannabis and cannabinoids may have benefits in treating the symptoms of cancer or the side effects of cancer therapies” (6)

“Cannabinoids may be useful in treating the side effects of cancer and cancer treatment” (7)

“Other possible effects of cannabinoids include:

• Anti-inflammatory activity.
• Blocking cell growth.
• Preventing the growth of blood vessels that supply tumors.
• Antiviral activity.
• Relieving muscle spasms caused by multiple sclerosis” (7)

“The main active cannabinoid in Cannabis is delta-9-THC. Another active cannabinoid is cannabidiol (CBD), which may relieve pain and lower inflammation without causing the “high” of delta-9-THC” (7)

“(THC) can help relieve pain and nausea, reduce inflammation, and can act as an antioxidant” (9)

“The researchers concluded that the THC:CBD extract was efficacious for pain relief in advanced cancer patients ” (5)

“Two small clinical trials of oral delta-9-THC showed that it relieved cancer pain” (7)

“CBD, in particular, is thought to have significant analgesic and anti-inflammatory activity without the psychoactive effect (high) of delta-9-THC” (4)

“CBD may alsenhance uptake of cytotoxic drugs into malignant cells” (4)

“Cannabidiol (CBD) can help treat seizures, can reduce anxiety and paranoia, and can counteract the “high” caused by THC” (9)

” CBD may make chemotherapy more effective and increase cancer cell death without harming normal cells” (7)

“CBD together with THC may enhance the antitumor activity of classic chemotherapeutic drugs” (4)

“One study in mice and rats suggested that cannabinoids may have a protective effect against the development of certain types of tumors” (4)

“Cannabinoids may cause antitumor effects by various mechanisms, including induction of cell death, inhibition of cell growth, and inhibition of tumor angiogenesis invasion and metastasis” (4)

“Cannabinoids appear to kill tumor cells but do not affect their non-transformed counterparts and may even protect them from cell death” (4)

“An in vitrstudy of the effect of CBD on programmed cell death in breast cancer cell lines found that CBD induced programmed cell death” (4)

“Cannabis has been shown to kill cancer cells in the laboratory” (6)

“Laboratory and animal studies have shown that cannabinoids may be able to kill cancer cells while protecting normal cells” (7)

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“A laboratory study of cannabidiol (CBD) in estrogen receptor positive and estrogen receptor negative breast cancer cells showed that it caused cancer cell death while having little effect on normal breast cells” (7)

“Studies in mouse models of cancer showed that CBD together with delta-9-THC may make chemotherapy such as temozolomide more effective” (7)

(11)